Endocannabinoid System

How can one herb help so many different conditions? How can it provide both palliative and curative actions? How can it be so safe while offering such powerful effects? The search to answer these questions has led scientists to the discovery of a previously unknown physiologic system, a central component of the health and healing of every human and almost every animal: The endogenous cannabinoid system, also known as the endocannabinoid system or ECS.

The ECS has three basic components: endocannabinoids, cannabinoid receptors, and hydrolytic enzymes that break down endocannabinoids. Endocannabinoids are molecules produced by cells that have activity similar to THC and the other phytocannabinoids (plant-derived cannabinoids). They are synthesized on the cell membrane from omega-6 fatty acid precursors. Both endo- and phytocannabinoids act on cannabinoid receptors, known as CB1 and CB2, found throughout the body. Stimulating the CB receptors leads to a variety of physiologic processes inside the cell. Finally, enzymes responsible for the breakdown and recycling of endocannabinoids, MAGL and FAAH, modulate the activity of the ECS.

Sea squirts, newts, rodents, and all vertebrate species share the endocannabinoid system as an essential part of life and adaptation to environmental changes. By comparing the genetics of cannabinoid receptors in different species, scientists estimate that the endocannabinoid system evolved in primitive animals over 600 million years ago, long before the cannabis plant evolved 34 million years ago.

The ECS is perhaps the most important physiologic system involved in establishing and maintaining human health.

 

Endocannabinoids and their receptors are found throughout the body: in the brain, organs, connective tissues, glands, and immune cells. In each tissue, the cannabinoid system performs different tasks, but the goal is always the same: homeostasis, the maintenance of a stable internal environment despite fluctuations in the external environment. Cannabinoids promote homeostasis at every level of biological life, from the sub-cellular, to the organism, and perhaps to the community and beyond.

Endocannabinoids are found at the intersection of the body’s various systems, allowing communication and coordination between different cell types. At the site of an injury, for example, cannabinoids can be found decreasing the release of activators and sensitizers from the injured tissue, stabilizing the nerve cell to prevent excessive firing, and calming nearby immune cells to prevent release of pro-inflammatory substances. Three different mechanisms of action on three different cell types for a single purpose: minimize the pain and damage caused by the injury.

The endocannabinoid system, with its complex actions in our immune system, nervous system, and all of the body’s organs, is literally a bridge between body and mind. By understanding this system we begin to see a mechanism that explains how states of consciousness can promote health or disease.

In addition to regulating our internal and cellular homeostasis, cannabinoids can influence a person’s relationship with the external environment. Socially, the administration of cannabinoids (especially THC) can alter human behavior, often promoting sharing, humor, and creativity. By mediating neurogenesis (the growth of new brain cells), neuronal plasticity (forming new connections between brain cells), and learning, cannabinoids may directly influence a person’s open-mindedness and ability to move beyond limiting patterns of thought and behavior from past situations. Reformatting these old patterns is an essential part of health in our quickly changing environment.

Natural Cannabis Compounds

Cannabinoids

Cannabinoids are plant substances that communicate and interact with specific cannabinoid receptors within the body's natuaral endocannabinoid system. Cannabinoids present in hemp can stimulate receptors in the regulation of processes like sleep, pain, mood, inflammation, and immune function. Cannabinoids are essential to the endocannabinoid system and maintaining balance and overall wellness. 

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Natural Flavor - Smell - Benefits

Terpenes

Terpenes are the aromatic chemicals produced by many plants, including hemp, which give the plant its unique smell and taste. Terpenes have recently started to attract scientists' attention because of their unusual properties and possible therapeutic applications. The terpenes aromas aid in their absorption and their combination with cannabinoids can amplify the effect of hemp CBD products.

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When CB1 & CB2 interact

The Entourage 

When a Hemp Oil product says FULL SPECTRUM, this means there is more in this cannabis product than a single molecule of CBD. Having multiple cannabinoids and terpenes in a hemp product creates what is known as the entourage effect.

Endocannabinoid System

ECS

The ECS is a group of endogenous cannabinoid receptors located in the mammalian brain and throughout the central and peripheral nervous system. These receptors create a sensory system in your body that when in balance, enhances your life by increasing creativity, energy, metabolism, and wellness.

Cannainoid Receptor Type 1

CB1

The CB1 receptors are found throughout your body but are concentrated in the brain. These receptors involve movement and the body's coordination, pain perception, appetite, memories and emotion and thinking. THC (the psychoactive compound) attaches to these CB1 receptors.

Cannabinoid Receptor Type 2

CB2

The CB2 receptors are more commonly found in your immune system and are involved with pain and inflammation. Scientists used to believe that CBD attached to these CB2 receptors but now more current research suggests that CBD does not attach to either receptor, but simply allows your body to use more of your own naturally produced cannabinoids.

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Disclaimer: The statements made regarding these products have not been evaluated by the Food and Drug Administration. The efficacy of these products has not been confirmed by FDA-approved research. These products are not intended to diagnose, treat, cure or prevent any disease. All information presented here is not meant as a substitute for or alternative to information from health care practitioners. Please consult your health care professional about potential interactions or other possible complications before using any product. The Federal Food, Drug and Cosmetic Act requires this notice.